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Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 473-480 doi: 10.1007/s11684-018-0657-5
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immuneOne mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signalreceptors are found to be expressed on TAMs, the corresponding therapies may also stimulate macrophages for phagocytosis
Keywords: CD47 PD-1 PD-L1 immunotherapy TAM phagocytosis macrophage
Applications of atomic force microscopy in immunology
Jiping Li, Yuying Liu, Yidong Yuan, Bo Huang
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 43-52 doi: 10.1007/s11684-020-0769-6
Keywords: cellular mechanics atomic force microscopy neutrophil extracellular trap macrophage phagocytosis pore
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 781-795 doi: 10.1007/s11684-023-0986-x
Keywords: dry eye disease glycolytic reprogramming pyroptosis inflammation 2-DG
Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,
Engineering doi: 10.1016/j.eng.2023.05.022
Keywords: Multidrug-resistant Escherichia coli Macrophage–Fe3O4@PLGA particles Biomimetic intelligent catalysis
Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang
Engineering 2023, Volume 20, Issue 1, Pages 63-76 doi: 10.1016/j.eng.2021.09.007
Keywords: Xuanfeibaidu Formula Multimodal identification Inflammation Macrophage activation Macrophage migration
Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 304-316 doi: 10.1007/s11684-022-0964-8
Keywords: macrophage glycoproteome glycopeptides N-glycan structures PD-L1
The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection Review
Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao
Engineering 2022, Volume 10, Issue 3, Pages 21-29 doi: 10.1016/j.eng.2021.10.015
Keywords: Macrophages Transplantation Tolerance Rejection Regulatory macrophage
Frontiers of Medicine 2023, Volume 17, Issue 4, Pages 699-713 doi: 10.1007/s11684-022-0972-8
Keywords: receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment tumor-associated macrophage
Mo Chen, Yuzhou Chen, Sijia Feng, Shixian Dong, Luyi Sun, Huizhu Li, Fuchun Chen, Nguyen Thi Kim Thanh, Yunxia Li, Shiyi Chen, You Wang, Jun Chen
Engineering doi: 10.1016/j.eng.2023.05.010
Skeletal muscle has a robust regeneration ability that is impaired by severe injury, disease, and aging, resulting in a decline in skeletal muscle function. Therefore, improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders. Owing to their significant role in tissue regeneration, implantation of M2 macrophages (M2Mø) has great potential for improving skeletal muscle regeneration. Here, we present a short-wave infrared (SWIR) fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2Mø transplantation. SWIR fluorescence imaging was employed to track implanted M2Mø in the injured skeletal muscle of mouse models. It is found that the implanted M2Mø accumulated at the injury site for two weeks. Then, SWIR fluorescence imaging of blood vessels showed that M2Mø implantation could improve the relative perfusion ratio on day 5 (1.09 ± 0.09 vs 0.85 ± 0.05; p = 0.01) and day 9 (1.38 ± 0.16 vs 0.95 ± 0.03; p = 0.01) post-injury, as well as augment the degree of skeletal muscle regeneration on day 13 post-injury. Finally, multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle regeneration. These results provide more in vivo details about M2Mø in skeletal muscle regeneration and confirm that M2Mø could promote angiogenesis and improve the degree of skeletal muscle repair, which will guide the research and development of M2Mø implantation to improve skeletal muscle regeneration.
Keywords: In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration
Title Author Date Type Operation
Activation of phagocytosis by immune checkpoint blockade
Chia-Wei Li, Yun-Ju Lai, Jennifer L. Hsu, Mien-Chie Hung
Journal Article
Applications of atomic force microscopy in immunology
Jiping Li, Yuying Liu, Yidong Yuan, Bo Huang
Journal Article
Hyperosmolarity promotes macrophage pyroptosis by driving the glycolytic reprogramming of corneal epithelial
Journal Article
Biomimetic Macrophage–Fe3O4@PLGA Particle-Triggered Intelligent Catalysis for Killing Multidrug-Resistant
Jieni Fu,Xiangmei Liu,Zhaoyang Li,Yufeng Zheng,Yu Zhang,Hui Jiang,Yanqin Liang,Shengli Zhu,Zhenduo Cui,Shuilin Wu,
Journal Article
by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated
Lu Zhao, Hao Liu, Yingchao Wang, Shufang Wang, Dejin Xun, Yi Wang, Yiyu Cheng, Boli Zhang
Journal Article
Application of StrucGP in medical immunology: site-specific -glycoproteomic analysis of macrophages
Journal Article
The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection
Liang Tan, Yinan Guo, Chang Feng, Yangxiao Hou, Xubiao Xie, Yong Zhao
Journal Article
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma upon anti-CD19 chimeric antigen receptor T therapy
Journal Article